Molecular Pathways: Oncologic Pathways and Their Role in T-cell Exclusion and Immune Evasion – A New Role for the AXL Receptor Tyrosine Kinase

Todd A. Aguilera and Amato J. Giaccia.
DOI: 10.1158/1078-0432.CCR-17-0189 Published January 2017

Targeting GAS6 in cancer, fibrosis and viral infection

Rebecca Miao, Amato Giaccia (Stanford University) and Raymond Tabibiazar (Aravive Biologics, Inc.).
Drug Target Review, 9 March 2017. Issue #1, 2017.

Axl Mediates ZIKA Virus Entry in Human Glial Cells and Modulates Innate Immune Responses

Laurent Meertens, Athena Labeau, Ophelie Dejarnac, Sara Cipriani, Laura Sinigaglia, Lucie Bonnet-Madin, Tifenn Le Charpentier, Mohamed Lamine Hafirassou, Alessia Zamborlini, Van-Mai Cao-Lormeau, Muriel Coulpier, Dorothée Missé, Nolwenn Jouvenet, Ray Tabibiazar, Pierre Gressens, Olivier Schwartz, Ali Amara.

DOI: http://dx.doi.org/10.1016/j.celrep.2016.12.045

Reprogramming the immunological microenvironment through radiation and targeting Axl.

Aguilera TA, Rafat M, Castellini L, Shehade H, Kariolis MS, Hui AB, Stehr H, von Eyben R, Jiang D, Ellies LG, Koong AC, Diehn M, Rankin EB, Graves EE, Giaccia AJ.

Nat Commun. 2016 Dec 23;7:13898. doi: 10.1038/ncomms13898.

Inhibition of the GAS6/AXL pathway augments the efficacy of chemotherapies

Kariolis MS, Miao YR, Diep A, Nash SE, Olcina MM, Jiang D, Jones DS 2nd, Kapur S, Mathews II, Koong AC, Rankin EB, Cochran JR, Giaccia AJ.

J Clin Invest. 2016 Nov 28. [Epub ahead of print]

PMID: 27893463

The Receptor Tyrosine Kinase AXL in Cancer Progression

Rankin EB, Giaccia AJ.

Cancers (Basel). 2016 Nov 9;8(11).

PMID: 27834845

Targeting MET and AXL overcomes resistance to sunitinib therapy in renal cell carcinoma

Zhou L, Liu XD, Sun M, Zhang X, German P, Bai S, Ding Z, Tannir N, Wood CG, Matin SF, Karam JA, Tamboli P, Sircar K, Rao P, Rankin EB, Laird DA, Hoang AG, Walker CL, Giaccia AJ, Jonasch E.

Oncogene. 2016 May;35(21):2687-97.

PMID: 26364599

An engineered Axl ‘decoy receptor’ effectively silences the Gas6-Axl signaling axis

Kariolis MS, Miao YR, Jones DS 2nd, Kapur S, Mathews II, Giaccia AJ, Cochran JR.

Nat Chem Biol. 2014 Nov;10(11):977-83.

PMID: 25242553

Direct regulation of GAS6/AXL signaling by HIF promotes renal metastasis through SRC and MET

Rankin EB, Fuh KC, Castellini L, Viswanathan K, Finger EC, Diep AN, LaGory EL, Kariolis MS, Chan A, Lindgren D, Axelson H, Miao YR, Krieg AJ, Giaccia AJ.

Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13373-8.

PMID: 25187556

AXL is an essential factor and therapeutic target for metastatic ovarian cancer

Rankin EB, Fuh KC, Taylor TE, Krieg AJ, Musser M, Yuan J, Wei K, Kuo CJ, Longacre TA, Giaccia AJ.

Cancer Res. 2010 Oct 1;70(19):7570-9.

PMID: 20858715